Organoid paper published in Cell Stem Cell

We published our first paper as part of the Infant Brain Imaging Study (IBIS) induced pluripotent stem cell (iPSC) project in Cell Stem Cell. We generated iPSCs from 18 participants in the infant brain imaging study who had longitudinal brain structural images acquired since infancy. Features from cortical organoids correlated with the brain growth of the individual from which they were derived. For example, gene expression at the crux of fate decisions between neural progenitor self renewal and neuronal differentiation were strongly associated with cortical surface area. Congrats to Rose Glass, Nana Matoba and all the wet, dry, and clinical labs that made such an ambitious project possible!