The Stein lab co-organized the Andrew S. Rachlin UNC Neuroscience Symposium this year. Thanks to Dan Geschwind and Flora Vaccarino for coming as our keynote speakers, and to all the local speakers for a fascinating seminar! Hope it leads to future collaborations and projects on tackling neuropsychiatric disorder genetics here in the triangle area.
We ran the 5k (Jason) and 10k (Tianyi) at the Walk for Hope to raise money for the Foundation of Hope. This is a great organization supporting research into mental health, including supporting some of our work. https://walkforhope.com/
Congratulations to PhD candidate Rose Glass for receiving a T32 Neuroscience Curriculum Training Grant through UNC!
Stein Lab and our collaborator Dr. Guorong Wu were invited to speak at the UNC ARVR Interest Group Meeting to demo our work with mapping a mouse brain in 3D and visualizing human brain networks using virtual reality.
"Come and join us for a talk by Dr. Jason Stein and Dr. Guorong Wu of the Neuroscience Center at UNC-Chapel Hill. Dr. Stein will be talking about his work using Virtual Reality to map the mouse brain in 3D. The mouse brain has over 100 million nuclei, and current approaches that to mapping each nucleus, which involves combining 2D data, is slow and cumbersome. Dr. Wu will demo his lab’s work on visualizing the human brain network. They will present a 3D virtual reality (VR) environment to visualize the human brain connectome data for neuroscience and clinical application. Their VR environment provides a user-friendly interface and allows users to interact with the display of region-to-region connectivity in the whole brain. In addition, they integrate computational component of brain network analysis, multi-channel data fusion scenario, and a set of auxiliary functions into our VR environment. These features make their VR environment an efficient and innovative platform to analyze human brain connectome data. All are welcome."
Zach Humphrey showing a fellow Tarheel our virtual reality system.
Rose Glass is a graduate student in the Biological and Biomedical Sciences Program in the Neuroscience Department at UNC-Chapel Hill. Welcome Rose!
Congratulations to our undergraduate student Tianyi Liu for being awarded the Summer Undergraduate Research Fellowship (SURF) from UNC-Chapel Hill! Tianyi was selected by Honors Carolina to receive a William W. and Ida W. Taylor Honors Mentored Research Fellowship within SURF. The competition for this award was intense, 135 applications from a variety of fields were received and only 62 were awarded. Stein Lab and SURF are looking forward to seeing the results from the fellowship.
Congratulations to Biomedical Engineering graduate student Oleh Krupa, who received a trainee travel award to attend the April 2018 BRAIN Initiative PI meeting in Washington, DC!
Our paper was just published in Cell on the Dynamic Landscape of Open Chromatin during Human Neurogenesis. In this paper, we've mapped previously unknown regulatory elements to genes during human neurogenesis - including with genetically engineered validation of novel regulatory elements of EOMES and FGFR11, we identified some novel transcription factors that may be related to human neurogenesis, and finally we found that genetic variation within proliferation related regulatory elements impacts adult brain size and risk for neuropsychiatric diseases.
The Committee on Faculty Research and Scholarly Leaves at UNC has awarded Jason a Junior Faculty Development Award!
Brandon Le joined Stein lab in Fall 2017 to help facilitate high throughput human neural progenitor cell culture projects. Welcome Brandon!
Congratulations to Mike Lafferty for receiving the Bioinformatics and Computational Biology NIH-supported training grant (T32 GM 067553)! Mike is a second year graduate student working on QTL analyses.
You can find here all the slides from the Introduction to Imaging Genetics course at the Organization for Human Brain Mapping 2017 in Vancouver, Canada. A picture of all the faculty from the course is below.
Mike Lafferty is a graduate student in the Bioinformatics and Computational Biology program who will be working on QTL analyses. Welcome Mike!
Here is a brief description of what we're doing in the Enhancing Neuroimaging Genetics through Meta-analsysis (ENIGMA) consortium. Thanks to Paul Thompson, Aggie McMahon, and Sophia Thomopoulos for putting this together!
Through a collaborative effort between the CHARGE and ENIGMA consortia, we identified 6 loci influencing the structure of the human hippocampus. Interestingly, genetic variants decreasing hippocampal volume in the general population are associated with increased risk for Alzheimer's disease. The study was published in Nature Communications.
We welcome 3 new members to the Stein lab! Shana Hall is a postdoc with Jessica Cohen and doing a postdoctoral rotation in our lab to work on imaging genetics projects. Zach Humphrey and Tianyi Liu are both undergraduates working on automated recognition of cells within 3D microscopy images of the brain.
Congrats to Hyejung Won in Dan Geschwind's lab for publishing a paper in Nature on chromatin interaction via Hi-C in the developing human brain. This paper gives new insights into the genes (mis)regulated by schizophrenia risk alleles. We find that genetic variants associated with risk for schizophrenia in non-coding and functionally undefined regions of the genome are physically interacting with some previously suspected genes as well as some new genes. One step closer to understanding the biological pathways creating genetic risk for a complicated psychiatric disease.
Our most recent paper of the Enhancing Neuroimaging Genetics through Meta-analysis consortium was just published in Nature Neuroscience. We identified 7 loci significantly influencing the structure of the human brain, some near very interesting neural genes (IGF1, FOXO3). Most interesting is the genetic correlation between intracranial volume and adult cognitive ability - the same genetic variants that influence the size of your brain also (in part) influence your cognitive ability later in life! Pretty exciting functional impacts of structural differences.
Along with Ashok Krishnamurthy of RENCI (co-PI) and Guorong Wu of the BRIC (co-PI), we were funded for our proposal to develop a unified computational framework for analysis, storage, and visualization of 3D brain microscopy data from the NSF.